Influence of Phyllanthus niruri Linn. Extract Therapy on Renal and Uterus in 2% NaCl -induced Fibrotic Scarring Rodents
Keywords:
Phyllanthus niruri extract, fibrosis, matrix extracelluer
Abstract
Background
Phyllanthus niruri (english name : leafflower) extract is used in therapy of renal and uterus fibrotic scarring disease. Influence of alcohol extract of P. niruri on renal and uterus of 2% NaCl- induced fibrotic scarring rodents had been researched.
Aim of Study
Purpose of this research to study the influence of leafflower (Phyllanthus niruri Linn.) therapy on renal and uterus in 2% NaCl - induced fibrotic scarring rodents.
Methods
Wistar rodents were stimulated with 2% NaCl in drinking water to induce fibrotic scarring renal and uterus. Phyllanthus niruri extract (200 mg/kg) was given orally for 4 weeks. Matrix extracellular expression was determined by HE Staining and calculated by METAVIR fibrosis scarring score. The data of this study were analyzed by SPSS 16.
Results
- niruri extract was able to decrease the matrix extracellular in 2% NaCl-induced rodent compared to control group (p<0.05).
Conclusion
P. niruri extract was able to decrease the matrix extracellular in the renal and uterus of the rodents.
References
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Yu, H.C.M, Burrell, L.M., Black, M.J., Wu, L.L., Dilley, R.J., 1998, Salt induces myocardial and renal fibrosis in normotensive and hypertensive rats. Circulation 98: 2621-2628.
Leenen, F.H.H., 2010, The central role of the brain aldosterone – “ouabain” pathway in salt-sensitive elevated blood pressure. BBA Mol Basis Dis 1802: 1132-1139.
Jöhren, O., Dendorfer, A., Dominiak, P., 2004, Cardiovascular and renal function of angiotensin II type-2 receptors. Cardiovasc Res 62: 460-467.
Starr, C., McMillan, B., 2012, Human Biology. 9th Edn, Brooks/Cole Cengage Learning, Canada.
Mezzano, S.A., Ruiz-Ortega, M., Egido, J., 2001, Angiotensin II and renal fibrosis. Elevated blood pressure 38: 635638.
Rotman, N., Wahli, W., 2010, PPAR modulation of kinase-linked receptor signaling in physiology and malady. Physiology 25: 176-185.
Grigorova, Y.N., Juhasz, O., Zernetkina, V., Fishbein, K.W., Lakatta, E.G., Fedorova, O.V., and Bagrov, A.Y., 2016. Aortic Fibrosis, Induced by High Salt Intake in the Absence of Hypertensive Response, Is Reduced by a Monoclonal Antibody to Marinobufagenin. American J. of Hypert. 29(5) : 641-646.
Amin, A.Z. et al., 2013. Gene expression profiling reveals underlying molecular mechanism of hepatoprotective effect of Phyllanthus niruri on thioacetamide-induced hepatotoxicity in Sprague Dawley rats. BMC Complementary and Alternative Medicine 2013, 13:160.
Manjrekar, A. P., Jisha, V., Bag, P. P., Adhikary, B., Pai, M. M ., Hegde, A ., & Nandini, M., 2008. Effect of Phyllanthus niruri Linn. treatment on liver, kidney and testes in CCl4 induced hepatotoxic rats. Indian J. Exp. Bio. 46: 514-520.
Giribabu, N., Karim, K., Kumar, E., Kilari, Salleh, N. 2017. Phyllanthus niruri leaves aqueous extract improves kidney functions, ameliorates kidney oxidative stress, inflammation, fibrosis and apoptosis and enhances kidney cell proliferation in adult male rats with diabetes mellitus. J Ethnopharmacol. 205:123-137.
Narayanan, B.S., Latha, P., & Rukkumani, R., 2010. Protective effects of Phyllanthus amarus on fibrotic markers during alcohol and polyunsaturated fatty acid-induced toxicity. Toxicol Mech Methods. 21(1):48-52.
Baltatzi, M.C.H. S., Hatzitolios A., 2011, Role of angiotensin converting enzyme inhibitors and angiotensin receptor blockers in elevated blood pressure of chronic renal organ malady and renoprotection. Hippokratia 15: 2732.
Blaustein, M.P., et al., 2012, How NaCl raises blood pressure: A new paradigm for the pathogenesis of saltdependentelevated blood pressure. Am J Physiol Heart Circ Physiol 302: H1031-H1049.
Cox, N., Pilling, D., Gomer, R.H., 2012, NaCl potentiates human fibrocyte differentiation. PLoS One 7: 1-9.
Beevers, G., Lip, G.Y.H,, O’Brien, E., 2001, ABC of elevated blood pressure: “The pathophysiology of elevated blood pressure”. BMJ 322: 912-916.
He, F.J., Jenner, K.H., MacGregor, G.A., Avenue, G., 2012, Telmisartan exerts renoprotective actions via peroxisome. Elevated blood pressure 59: 308-316.
Meneton, P., et al., 2005, Links between dietary salt intake, renal salt handling, blood pressure and cardiovascular maladys. Physiol Rev 86: 679-715.
Yu, H.C.M, Burrell, L.M., Black, M.J., Wu, L.L., Dilley, R.J., 1998, Salt induces myocardial and renal fibrosis in normotensive and hypertensive rats. Circulation 98: 2621-2628.
Leenen, F.H.H., 2010, The central role of the brain aldosterone – “ouabain” pathway in salt-sensitive elevated blood pressure. BBA Mol Basis Dis 1802: 1132-1139.
Jöhren, O., Dendorfer, A., Dominiak, P., 2004, Cardiovascular and renal function of angiotensin II type-2 receptors. Cardiovasc Res 62: 460-467.
Starr, C., McMillan, B., 2012, Human Biology. 9th Edn, Brooks/Cole Cengage Learning, Canada.
Mezzano, S.A., Ruiz-Ortega, M., Egido, J., 2001, Angiotensin II and renal fibrosis. Elevated blood pressure 38: 635638.
Rotman, N., Wahli, W., 2010, PPAR modulation of kinase-linked receptor signaling in physiology and malady. Physiology 25: 176-185.
Grigorova, Y.N., Juhasz, O., Zernetkina, V., Fishbein, K.W., Lakatta, E.G., Fedorova, O.V., and Bagrov, A.Y., 2016. Aortic Fibrosis, Induced by High Salt Intake in the Absence of Hypertensive Response, Is Reduced by a Monoclonal Antibody to Marinobufagenin. American J. of Hypert. 29(5) : 641-646.
Amin, A.Z. et al., 2013. Gene expression profiling reveals underlying molecular mechanism of hepatoprotective effect of Phyllanthus niruri on thioacetamide-induced hepatotoxicity in Sprague Dawley rats. BMC Complementary and Alternative Medicine 2013, 13:160.
Manjrekar, A. P., Jisha, V., Bag, P. P., Adhikary, B., Pai, M. M ., Hegde, A ., & Nandini, M., 2008. Effect of Phyllanthus niruri Linn. treatment on liver, kidney and testes in CCl4 induced hepatotoxic rats. Indian J. Exp. Bio. 46: 514-520.
Giribabu, N., Karim, K., Kumar, E., Kilari, Salleh, N. 2017. Phyllanthus niruri leaves aqueous extract improves kidney functions, ameliorates kidney oxidative stress, inflammation, fibrosis and apoptosis and enhances kidney cell proliferation in adult male rats with diabetes mellitus. J Ethnopharmacol. 205:123-137.
Narayanan, B.S., Latha, P., & Rukkumani, R., 2010. Protective effects of Phyllanthus amarus on fibrotic markers during alcohol and polyunsaturated fatty acid-induced toxicity. Toxicol Mech Methods. 21(1):48-52.
Published
2023-08-26
How to Cite
Pahmi, K., Nufus, L., & Andayani, D. (2023). Influence of Phyllanthus niruri Linn. Extract Therapy on Renal and Uterus in 2% NaCl -induced Fibrotic Scarring Rodents. Jurnal Ilmu Kesehatan Dan Farmasi, 11(1), 41 - 43. https://doi.org/10.51673/jikf.v11i1.1747
Section
Articles
